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“Our purpose is to know female reproductive getting older, and why fertility speedily declines starting up while in the mid-30s,” claims Satoshi Namekawa, a professor of Microbiology and Molecular Genetics, in whose lab Munakata functions.
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Utilizing the GCRLE grant, Munakata and Namekawa will glimpse more closely at how oocytes are genomically primed and stored for later use. They may look into the role of a chromatin remodeler in oocyte survival and fertility.
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Significant protein machines, identified as chromatin remodelers, can shift the positions of spools up and down the DNA thread, therefore facilitating the expression — or silencing — of Countless genes.
“The organization of chromatin influences which genes could be expressed,” claims Namekawa. That’s because the specific places on the spools, as well as spacing in between them, determines which stretches of DNA could be accessed by molecules called transcription aspects, which latch on to genes and switch them on.
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